Subgroup of Reproductive Functions of Progesterone Mediated by Progesterone Receptor-B Isoform
作者： Biserka Mulac-Jericevic , Robert A Mullinax , Francesco J DeMayo , John P Lydon , Orla M Conneely
DOI: 10.1126/SCIENCE.289.5485.1751
关键词:
摘要: Progesterone regulates reproductive function through two intracellular receptors, progesterone receptor-A (PR-A) and receptor-B (PR-B), that arise from a single gene as transcriptional regulators of progesterone-responsive genes. Although in vitro studies show PR isoforms can display different regulatory activities, their physiological significance is unknown. By selective ablation PR-A mice, we the PR-B isoform modulates subset functions by regulation target Thus, are functionally distinct mediators action vivo should provide suitable targets for generation tissue-selective progestins.
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