In Vitro Models of Brain Cancer

摘要: Glioblastoma multiforme (GBM) is the most common primary brain malignancy in adults. Despite continuing advances surgical treatment and combined chemoradiotherapy, little improvement overall median survival has been seen. Therapeutic neuro-oncology are likely to arise through systematic dissection of fascinating tumor biology that exists GBM. If we tackle questions such as “What cell origin cancer?” “How do these cells evade standard methods ultimately identify Achilles’ heel this aggressive disease?” a scientific prerequisite availability robust reliable vitro model glioma. What follows chapter discussion current state knowledge generation models glioblastoma. Past will be considered with their advantages shortcomings highlighted. We discuss principles cytotoxic assays how translatable therapies emerge from approach. mutation GBM modeling oncogenic transformation can shed new light on controversial topic. This chapter, hope, function timeline evolution cancer. It illustrates far have come our understanding cancer but additionally highlights barriers face must overcome ensure cure remains within sight.