Cytogenetics of human brain tumors

摘要: The most frequent cytogenetic alterations in primary brain tumors are losses of chromosomes or chromosomal regions and the presence double minute (dmins). which lost genes amplified distinctive for individual tumor types. Most malignant gliomas contain gains chromosome 7 10; 22, 9p, sex occur subgroups cases. gene frequently with dmins is epidermal growth factor receptor gene. Medulloblastomas have 17p cases c-myc amplification. Meningiomas deletions 22. Identification these specific abnormalities human has provided framework identifying them identified likely to suppressor genes, loss inactivation important development tumors.