Stimulation of human prostatic carcinoma tumor growth in athymic mice and control of migration in culture by extracellular matrix.

摘要: The tumorigenicity, migration, growth and invasiveness of certain tumor cells is stimulated by basement membranes. Here we have examined the effect Matrigel, an extract membrane proteins, on behavior several prostate cancer cell lines, testing their in vitro vivo. Cells Tsu-prI line were more invasive than PC-3, Du-145, or LNCaP cells. Peptide inhibitors implicated laminin migration invasion these When suspended Matrigel injected into nude mice, was greatly enhanced, since large tumors formed athymic mice whereas virtually no observed absence Matrigel. a slowly growing line, LNCaP, increased exogenous basic fibroblast factor when with A adhesion peptide, YIGSR, potent inhibitor Matrigel-stimulated implicating cell-laminin interactions this process. These results suggest that adenocarcinoma may be dependent both cellular factors cell-matrix mediated which facilitate development transplanted mice.