Molecular imaging of neuroendocrine tumors.

摘要: Molecular imaging represents tissue-specific and quantification of physiologically functional molecular events in tumors, utilizing new noninvasive modalities. It combines anatomic, physiologic metabolic information a single session. Neuroendocrine tumors (NETs) present unique features to use specific nuclear imaging, such as somatostatin receptor scintigraphy (SRS), metaiodobenzylguanidine scans PET scanning. NETs express receptors on tumor cells can, thus, be visualized by 111In-gadolinium-diethylenetriame pentaacetic acid-octreotide (OctreoScan®), which is currently the most common scanning technique for NETs. Every patient with NET should subjected SRS. Technetium-labeled analogs are growing importance. Metaiodobenzylguanidine was previously only method detection follow-up NETs, but nowadays more or less replaced octreotide During last decade, has been developed patients clearly demonstrated highest sensitivity specificity range 85-95%. detects smaller down 3 mm, compared SRS, size limit approximately 1 cm. 68Ga-DOTA-octreotide will, future, replace SRS owing its higher specificity, also reduce time investigation. will offer possibility evaluate number tumor. In readily available expensive, it possible study biology, vascularization gene expression development tracers.