Systemic administration of Met-enkephalin, (D-Ala2)-Met-enkephalin, β-endorphin, and (D-Ala2)-β-endorphin: Effects on eating, drinking and activity measures in rats
作者： Maurice G. King , Abba J. Kastin , Richard D. Olson , David H. Coy
DOI: 10.1016/0091-3057(79)90116-3
关键词: Met-enkephalin 、 Acetic acid 、 Systemic administration 、 Food intake 、 Chemistry 、 Enkephalin 、 Endocrinology 、 Water intake 、 Internal medicine 、 Wheel running
摘要: Rats were given four daily, interperitoneal injections (80 μg/kg) of Met-enkephalin, (D-Ala2)-Met-enkephalin-NH2, β-endorphin, (D-Ala2)-β-endorphin or the diluent (0.9% NaCl acidified to, 0.01 M with acetic acid). Animals subsequently tested for food and water intake activity. Met-enkephalin did not affect any measures but its (D-Ala2) analog reduced some activity in a complicated way. β-Endorphin intake; familiar situations these animals less active while novel seemed to potentiate The wheel running over 24 hours.
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