Moderate chronic administration of Vineatrol-enriched red wines improves metabolic, oxidative, and inflammatory markers in hamsters fed a high-fat diet

摘要: Scope High-fat (HF) diets contribute to the development of cardiovascular diseases and metabolic syndrome. This study was undertaken investigate beneficial effects Vineatrol®-enriched red wines on blood lipids, oxidative stress inflammation, role some pathway regulatory proteins. Methods results Golden Syrian hamsters received an HF diet for 13 wk, in presence or absence supplemented with Vineatrol® (RWV) not. The increased plasma cholesterol, triglycerides, glucose, insulin, which were attenuated by RWV treatment. protected against HF-induced increase liver nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity spared antioxidant enzyme activities. did not reduce either steatosis leptin due diet, but greatly improved adiponectinemia. In liver, affected inflammatory response decreasing polymorphonuclear cell number lowering TNF-α IL-6 levels. Moreover, NF-κB group prevented RWV. Finally, partially corrected low SIRT1 levels had no influence SIRT3 p-AMPK protein levels. Conclusion Our studies suggest that is capable reversing atherogenic process induced hamster tissues.