Ex vivo lipopolysaccharide‐induced interleukiri‐1 secretion from murine peritoneal macrophages inhibited by probucol, a hypocholesterolemic agent with antioxidant properties

摘要: Probucol, 4,4'-(isopropylidenedithio)bis(2,6-di-tert-butyl-phenol), has been shown to inhibit atherogenesis in genetically hypercholesterolemic (Watanabe) rabbits. Since atherosclerotic lesions contain macrophages capable of screting interleukin 1 (IL 1) and other cytokines that could contribute the pathogenesis disease, we have investigated whether probucol affects IL secretion. Resident peritoneal from mice dosed with secreted 40-80% less than control animals when stimulated vitro lipopolysaccharide (LPS). The inhibitory effect was observed assayed by standard bioassay, thymocyte proliferation assay, or a competitive receptor binding assay. Probucol treatment had no on LPS-induced membrane expression; secretion tumor necrosis factor (TNF); Con A-induced splenic 2 2) 3 3) release; prostaglandin- zymosan-induced prostacyclin, leukotrie...