Cyclin D1 expression in the intestinal mucosa and tumors of Apc1638N mice.

摘要: Altered expression of cyclin D1 contributes to the development several types cancer, including colorectal cancer. This study examined in 32 intestinal tumors different stages tumorigenesis Apc1638N mice, a mouse model for human familial adenomatous polyposis (FAP). Three morphological patterns epithelial cells were found: nuclear, punctate-cytoplasmic and fine granular cytoplasmic. The nuclear pattern was detected all tumors, adenomas (n = 18) adenocarcinomas 14); this found predominantly tubular region flat mucosa adjacent subset (67% 57% carcinomas). majority (80%), mainly invasive villous areas tumors; it not normal suggesting that altered cytoplasmic/nuclear associated with tumor progression. Fine cytoplasmic granules located duodenum basal portion crypts colon at surface colonic crypts; both number significantly increased after feeding Western-style diet. These may provide useful biomarkers abnormal cell studies effects chemopreventive agents.