Chemoprevention of colon cancer by calcium, vitamin D and folate: molecular mechanisms

作者: Sergio A. Lamprecht , Martin Lipkin

DOI: 10.1038/NRC1144

关键词: Regulation of gene expressionSignal transductionClinical trialCalciumMicronutrientPharmacologyVitamin D and neurologyCalcium-vitamin DColorectal cancerBiology

摘要: … If so, is the BAK gene promoter under the direct transcriptional control of vitamin D or is its regulation an indirect response to the cascade of events induced in colon cells after exposure …

参考文章(144)
S. J. James, Sang Woon Choi, Y.-I. Kim, I. P. Pogribny, R. N. Salomon, D. E. Smith, J. B. Mason, Exon-specific DNA hypomethylation of the p53 gene of rat colon induced by dimethylhydrazine. Modulation by dietary folate. American Journal of Pathology. ,vol. 149, pp. 1129- 1137 ,(1996)
N. Rhue, Y. Hirooka, T. Mitsuma, Jing Ping, Y. Yokoi, M. Kayama, Y. Mori, T. Nogimori, K. Adachi, Distribution of calcium sensing receptor in rats: an immunohistochemical study. Endocrine Regulations. ,vol. 33, pp. 55- 59 ,(1999)
Bert Vogelstein, Kornelia Polyak, Kenneth W. Kinzler, Stanley R. Hamilton, Early alteration of cell-cycle-regulated gene expression in colorectal neoplasia. American Journal of Pathology. ,vol. 149, pp. 381- 387 ,(1996)
Bret A. Lashner, Paul A. Heidenreich, Grace L. Su, Sunanda V. Kane, Stephen B. Hanauer, Effect of folate supplementation on the incidence of dysplasia and cancer in chronic ulcerative colitis: A case-control study Gastroenterology. ,vol. 97, pp. 255- 259 ,(1989) , 10.1016/0016-5085(89)90058-9
E. Kállay, M. Peterlik, H. S. Cross, F. Wrba, S. Kriwanek, E. Bajna, Dietary calcium and growth modulation of human colon cancer cells: role of the extracellular calcium-sensing receptor. Cancer Detection and Prevention. ,vol. 24, pp. 127- 136 ,(2000)
Raju Kucherlapati, Winfried Edelmann, I. Bernard Weinstein, Kunhua Fan, Kan Yang, Martin Lipkin, Hiroharu Shinozaki, Cyclin D1 expression in the intestinal mucosa and tumors of Apc1638N mice. Anticancer Research. ,vol. 23, pp. 2217- 2226 ,(2003)
Michael J. Berridge, Martin D. Bootman, H. Llewelyn Roderick, Calcium signalling: dynamics, homeostasis and remodelling. Nature Reviews Molecular Cell Biology. ,vol. 4, pp. 517- 529 ,(2003) , 10.1038/NRM1155
J. M. Moseley, G. E. Moore, T. J. Martin, J. A. Eisman, L. J. Suva, R. J. Frampton, D. M. Findlay, Presence of 1,25-Dihydroxyvitamin D3 Receptors in Established Human Cancer Cell Lines in Culture Cancer Research. ,vol. 42, pp. 1116- 1119 ,(1982)
Lawrence J. Burgart, William E. Karnes, Irene K. Klein, Patrick C. Roche, Sandra J. Gendler, Steven R. Ritland, Steven C. Ziesmer, Adenoma-specific alterations of protein kinase C isozyme expression in Apc(MIN) mice Cancer Research. ,vol. 60, pp. 2077- 2080 ,(2000)
Erik JM Konings, R Alexandra Goldbohm, Henny AM Brants, Wim HM Saris, Piet A van den Brandt, None, Intake of dietary folate vitamers and risk of colorectal carcinoma: results from The Netherlands Cohort Study. Cancer. ,vol. 95, pp. 1421- 1433 ,(2002) , 10.1002/CNCR.10866