TiNOx coatings on roughened titanium and CoCr alloy accelerate early osseointegration of dental implants in minipigs

摘要: Abstract Introduction Titanium nitride oxide (TiNOx) coatings are known for their biocompatibility, hardness and high resistance to corrosion wear. Further, they can be applied by plasma vapor deposition onto a wide variety of metallic, mineral, or organic substrates. In cell cultures, TiNOx SLA (sandblasted, large grit, acid etched)-roughened titanium surfaces increased human primary osteoblast proliferation 1.5 times in the first 2 weeks after seeding, while maintaining degree differentiation. Therefore, objectives present study were (i) determine whether these findings would translate into enhanced osseointegration TiNOx-coated implants vivo (ii) compare Ti-SLA (titanium–SLA) CoCr-SLA (cobalt–chromium–SLA) coated with TiNOx. Methods Forty‐eight cylinders made Ti-SLA, Ti-SLA-TiNOx (TiNOx‐coated Ti-SLA) CoCr-SLA-TiNOx CoCr-SLA) implanted lower jawbone 8 minipigs. The bone-to-implant contact was determined 1 week, 2 weeks, 1 month 3 months. Results Osseointegration proceeded normally on all 3 surfaces, equal activity week healing. After 1.8 higher coatings, either deposited Ti CoCr. These differences fell off 1 3 months Conclusions When compared standard titanium, enhance implant during month Furthermore, this stimulating effect is independent substrate, leading similar results coating SLA-Ti SLA-CoCr.