One-year weight maintenance after significant weight loss in healthy overweight and obese subjects: does diet composition matter?

摘要: Background: For many people, maintenance of weight loss is elusive. Whereas high-protein (HP) diets have been found to be superior high-carbohydrate (HC) for in the short term, their benefits long term are unclear, particularly maintenance. Furthermore, literature lacks consensus on long-term effects an HP diet cardiovascular disease risk factors. Objective: The objective was investigate whether macronutrient dietary composition plays a role and improvement Design: study comprised 2 phases. Phase 1 featured verylow-energy 3 mo. In phase 2, subjects were randomly assigned or HC 12 isocaloric, tightly controlled, individually prescribed overweight obese but otherwise healthy men women. Results: lost average 16.5 kg during maintained mean (6SEM) 14.5 6 1.2 (P , 0.001) 2; no significant differences between groups observed. By end study, reductions systolic blood pressure 14.3 2.4 mm Hg group 7.7 2.2 0.045). Forty-seven percent 180 who began completed both Conclusions: results indicate that protein carbohydrate content has effect successful weight-loss A general linear model analysis indicated treatment (HP HC) factor change favor diet. This trial registered at www.clinicaltrials.gov as NCT 00625236. Am J Clin Nutr doi: 10.3945/ajcn.2008.27209.