High OX-40 expression in the tumor immune infiltrate is a favorable prognostic factor of overall survival in non-small cell lung cancer

摘要: OX-40 co-stimulatory signaling plays a role in mounting anti-tumor immune responses and clinical trials targeting this pathway are ongoing. However, the association of with protein expression outcomes pathological features non-small cell lung cancer (NSCLC) largely unknown. Surgically-resected stage I-III NSCLC specimens (N = 100) were stained by immunohistochemistry (IHC) for following markers: OX-40, PD-L1, PD-1, CD3, CD4, CD8, CD45RO, CD57, CD68, FOXP3, granzyme B, ICOS. Immune-related markers mRNA also assessed. We evaluated levels major clinicopathologic variables, including molecular driver mutations. IHC was observed all tested tumors, predominantly localized membrane tumor infiltrate, not associated specific or subtype. High measured median score better overall survival (OS) (p = 0.002), independent CD3/CD8, ICOS expression. increased immune-related genes such as IFN-gamma, ICOS, CXCL9, CXCL10, CCL5, K. infiltrate is favorable prognosis IFN-gamma patients surgically resected NSCLC. Its prognostic utility PD-L1 other common activation. potentially identifies unique subgroup that may benefit from co-stimulation agonist antibodies enhance efficacy existing checkpoint therapies.