CD4+ T cells in cancer stroma, not CD8+ T cells in cancer cell nests, are associated with favorable prognosis in human non‐small cell lung cancers

作者: Osamu Wakabayashi , Koichi Yamazaki , Satoshi Oizumi , Fumihiro Hommura , Ichiro Kinoshita

DOI: 10.1111/J.1349-7006.2003.TB01392.X

关键词: Lung cancerCancer researchCancer cellImmune systemSurvival rateBiologyCD8PathologyCarcinomaCytotoxic T cellT lymphocyte

摘要: … of CD8+ T cells within cancer cell nests and the prognosis of the patients. Overall survival rates were lower in patients with higher numbers of CD8+ T cells within cancer cell nests than …

参考文章(32)
Hiromitsu Hiroumi, Hirotoshi Dosaka-Akita, Takayuki Mishina, Ichiro Kinoshita, Fumihiro Hommura, Yoshikazu Kawakami, Kenji Akie, Motoi Nishi, Altered p16INK4 and Retinoblastoma Protein Status in Non-Small Cell Lung Cancer: Potential Synergistic Effect with Altered p53 Protein on Proliferative Activity Cancer Research. ,vol. 56, pp. 5557- 5562 ,(1996)
Hirotoshi Dosaka-Akita, Hiroyuki Katoh, Takayuki Mishina, Shigeaki Ogura, Fumihiro Hommura, Michio Shimizu, Yoshikazu Kawakami, A Risk-Stratification Model of Non-Small Cell Lung Cancers Using Cyclin E, Ki-67, and ras p21 Different Roles of G1 Cyclins in Cell Proliferation and Prognosis Cancer Research. ,vol. 61, pp. 2500- 2504 ,(2001)
Gerald Willimsky, Thomas Blankenstein, Interleukin-7/B7.1-encoding adenoviruses induce rejection of transplanted but not nontransplanted tumors. Cancer Research. ,vol. 60, pp. 685- 692 ,(2000)
Oliver Howard Beahrs, Max H. Myers, Manual for Staging of Cancer ,(1992)
Hiroshi Nagura, Haruo Ohtani, Akio Ohuchi, Kenichi Shiiba, Yoshitaka Naito, Kazuya Saito, Katsunori Saigenji, CD8+ T Cells Infiltrated within Cancer Cell Nests as a Prognostic Factor in Human Colorectal Cancer Cancer Research. ,vol. 58, pp. 3491- 3494 ,(1998)
Jørgen Kjærgaard, Shigehiko Mukai, Gregory E. Plautz, Suyu Shu, Infiltration of Tumors by Systemically Transferred Tumor-Reactive T Lymphocytes Is Required for Antitumor Efficacy Cancer Research. ,vol. 59, pp. 5245- 5249 ,(1999)
J W Rohrer, J H Coggin, CD8 T cell clones inhibit antitumor T cell function by secreting IL-10. Journal of Immunology. ,vol. 155, pp. 5719- 5727 ,(1995)
Satoshi Oizumi, Koichi Yamazaki, Manabu Nakashima, Takeshi Watanabe, Fumihiro Hommura, Shigeaki Ogura, Masaharu Nishimura, Hirotoshi Dosaka-Akita, RCAS1 expression: a potential prognostic marker for adenocarcinomas of the lung. Oncology. ,vol. 62, pp. 333- 339 ,(2002) , 10.1159/000065065
Kohichi Yamazaki, Hironori Takekawa, Noriaki Sukoh, Naomi Watanabe, Shigeaki Ogura, Isao Nakajima, Hiroshi Isobe, Yoshikazu Kawakami, Shosaku Abe, Kazuaki Inoue, Tumor angiogenesis in human lung adenocarcinoma. Cancer. ,vol. 74, pp. 2245- 2250 ,(1994) , 10.1002/1097-0142(19941015)74:8<2245::AID-CNCR2820740807>3.0.CO;2-X
Charles M Balch, Lee B Riley, Yoon Joo Bae, Marie A Salmeron, Chris D Platsoucas, Andrew Von Eschenbach, Kyogo Itoh, Patterns of Human Tumor-Infiltrating Lymphocytes in 120 Human Cancers Archives of Surgery. ,vol. 125, pp. 200- 205 ,(1990) , 10.1001/ARCHSURG.1990.01410140078012