Naturally occurring chronic gastritis and C pylori infection in the rhesus monkey: a potential model for gastritis in man.

摘要: Histological examination of the stomachs Rhesus monkeys at autopsy showed chronic gastritis in a high proportion all ages. Lesions consisted mild to heavy infiltration lamina propria by lymphocytes, plasma cells, and histiocytes. The antrum was most consistently affected, but lesions were also present fundus pylorus. Gastric Campylobacter-like organisms (GCLO) apparently identical human C pylori cultured and/or detected immunohistologically several animals. Electron microscopy spiral bacteria on epithelial surface gastric pits. They did not penetrate cells intimately attached apical membrane caused loss microvilli. Antibodies serum ELISA. immunospecificity this antibody response confirmed Western blotting techniques. A small number cynomolgus examined had gastritis, which may be associated with presence pylori. Baboons have nor from their stomachs. study indicates that monkey has naturally occurring infection therefore suitable experimental animal for disease.