c-Met expression and MET amplification in malignant pleural mesothelioma

摘要: c-Met is a receptor tyrosine kinase shown to be overexpressed in malignant pleural mesothelioma (MPM). Whereas MET mutations have been identified 3%-16% of MPMs, amplification has recently reported single epithelioid MPM. We studied expression and large MPM cohort correlated results with morphologic clinical features. report the first case sarcomatoid MPMs from surgical pathology files (1989-2014) were reviewed. immunohistochemistry was performed. Staining intensity distribution multiplied (H-score). localization (cytoplasmic and/or membranous) noted. Fluorescence situ hybridization performed using probes for centromere 7. One hundred forty-nine patients (median age, 68.0years; interquartile range, 61-75) had (n=97), biphasic (n=18), or (n=34) Median follow-up 10.1months (range, 0.1-222.5). thirty died disease; 2 alive disease. expressed 147 MPMs. staining intensity, distribution, H-score differed among histologic subtypes (P=.015; P=.0001, P=.0005, respectively), but none predictive survival. Epithelioid subtype greater expression. 1 duplication MPM; both poor outcomes. Chromosome 7 aneusomy observed 54 144 (37.5%) associated decreased overall survival (hazard ratio=2.81; 95% confidence interval, 1.21-6.51; P=.01). In conclusion, MPM, significant differences subtypes. rare event making it an unlikely common pathogenesis