Induced hypertension treatment to improve cerebral ischemic injury after transient forebrain ischemia.

摘要: Abstract The effect of induced hypertension treatment on cerebral ischemia is still controversial. We investigated the preferred blood pressure manipulation level and pressor agent required to reduce ischemic injury following transient forebrain by bilateral occlusion common carotid arteries in anesthetized gerbils. Following 60-min ischemia, we evaluated treat after reperfusion examining effects different levels mean arterial (MABP), increased with phenylephrine or angiotensin II decreased withdrawal, flow (CBF), survival ratio, edema, brain energy metabolism Mild phenylephrine-induced (21±4 mmHg) during post-cerebral ischemia–reperfusion improved ratio reduced which was also associated an increase local CBF a recovery metabolism. However, intense hypertension, II-induced hypotension worsen rate produced extra that were deterioration These results demonstrate mild mmHg above baseline level) reduction edema improves Furthermore, may have neurotoxic use as for ischemia.