Increased Prevalence of Anti-Third Generation Cyclic Citrullinated Peptide Antibodies in Patients With Rheumatoid Arthritis and CREST Syndrome

摘要: To investigate the prevalence of anti-third generation cyclic citrullinated peptide antibodies (anti-CCP3) in patients with systemic connective tissue diseases, we assembled a training set consisting 115 rheumatoid arthritis (RA), 52 Calcinosis, Raynaud’s phenomenon, oesophageal dysmotility, sclerodactyly, telangiectasia (CREST) syndrome, 21 scleroderma, 20 ankylosing spondylitis, 18 reactive arthritis, 25 juvenile 51 osteoarthritis, 26 mixed disease, 23 primary Sjogren’s 74 lupus erythematosus, 49 Polymyaglia rheumatica, and 39 polymyositis/dermatomyositis. The commercial enzyme-linked immunosorbent assay (ELISA) was used to detect anti-CCP antibodies, including anti-CCP2 (regular, second CCP antigen) anti-CCP3 (third disease-related specimens normal controls. These serum samples were also evaluated for anti-centomere by anti-centromere ELISA kit. higher frequencies detected 75.6 70.4% RA, respectively. At same time, (not anti-CCP2) significantly increased isolated from CREST syndrome. clinical sensitivity IgG syndrome 29% (15 52) specificity 96% (384 397), exception RA group. only. results our study suggest that compared assay, new can enhance diagnosis and, as an associate marker combined anti-centromoere, distinguish other especially RA. lower than because crossreaction