Folate conjugated Mn3O4@SiO2 nanoparticles for targeted magnetic resonance imaging in vivo
作者： Xinyi Yang , Zhiguo Zhou , Li Wang , Caizhi Tang , Hong Yang
DOI: 10.1016/J.MATERRESBULL.2014.05.023
关键词: Nanoparticle 、 Nanostructure 、 Ethylene glycol 、 Silanization 、 Colloid 、 Crystallography 、 Ligand 、 Conjugated system 、 Covalent bond 、 Materials science 、 Organic chemistry
摘要: Graphical abstract: The Mn{sub 3}O{sub 4}@SiO{sub 2}(PEG)–FA has been used as a T{sub 1}-MRI probe for in vivo. - Highlights: • PEG and FA modified 2} nanoparticles (Mn{sub 2}–FA) were prepared. 2}–FA exhibited the good colloidal stability simulated biological medium. showed targeting ability to HeLa cells overexpressed receptor. 1}-weighted magnetic resonance (MR) imaging demonstrated of vivo tumor. Abstract: monodisperse silica-coated manganese oxide NPs) synthesized via high temperature pyrolysis approach aminated through silanization. amine-functionalized 4} NPs enabled covalent conjugation hydrophilic methoxypoly(ethylene glycol) (PEG) ligand folate (FA) onto their surface. formed 2}(PEG)–FA) medium inductively coupled plasma atomic emission spectroscopy (ICP-AES) analysis further targetingmore » tumor.« less
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