Nitric Oxide Synthase Expression in the Endothelium of Pulmonary Arterioles in Normal and Pulmonary Hypertensive Chickens Subjected to Chronic Hypobaric Hypoxia

摘要: Abstract SUMMARY. To determine whether or not exposure to chronic hypoxia and subsequent development of pulmonary hypertension syndrome (PHS) induce alterations in endothelial nitric oxide (NO) production broiler's vascular bed broilers, we studied the expression synthase enzyme cells by a nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase histochemical staining reaction. For this purpose, 60 broilers three different ages (17, 30, 42 days) were used. The animals distributed two groups: a) 30 healthy (nonhypertensive) b) chicks with PHS. All group b had fewer NADPH-diaphorase-positive arterioles than did nonhypertensive broilers. These differences highly significant (P < 0.01). results demonstrate for, first time that hypoxia-induced is associated decrease endothelial-derived NO vessels.