Reagents for the detection of protein phosphorylation in leukemia signaling pathways
作者： Roberto Polakiewicz , Albrecht Moritz , Valerie Goss , Kimberly Lee , Ting-Lei Gu
DOI:
关键词: Phosphorylation 、 Immunoglobulin superfamily 、 Biochemistry 、 G protein 、 Signal transduction 、 Guanine nucleotide exchange factor 、 Scaffold protein 、 Protein phosphorylation 、 Chemistry 、 Kinase
摘要: The invention discloses nearly 288 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human Leukemia, provides phosphorylation-site specific antibodies heavy-isotope labeled peptides (AQUA peptides) for the selective detection quantification of these phosphorylated sites/proteins, as well methods using reagents such purpose. Among are occurring following protein types: Adaptor/Scaffold proteins, Cytoskeletal Cellular Metabolism enzymes, G Protein/GTPase Activating/Guanine Nucleotide Exchange Factor Immunoglobulin Superfamily Inhibitor Lipid Kinases, Nuclear DNA Repair/RNA Binding/Transcription Serine/Threonine Protein Tyrosine Phosphatases, Translation/Transporter proteins.
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