Liposomes as Carriers for in Vivo Transfer and Expression of the Insulin Gene

作者: C. Nicolau , A. Legrand , E. Grosse

DOI: 10.1007/978-3-0348-6513-5_12

关键词: Insulin GeneCell biologyLong latencyChemistrySpleenIn vivoLiposome

摘要: Recent studies have shown that, when injected intravenously, liposomes are taken up mainly in the liver and spleen by macrophages of reticulo-endothelial system (2–5). Intravenous injection liposome entrapped molecules having long latency periods allows transport substantial amounts such to cellular sites uptake, i.e., splenic Kupffer cells (4,).

参考文章(31)
R. Fraley, S. Subramani, P. Berg, D. Papahadjopoulos, Introduction of liposome-encapsulated SV40 DNA into cells. Journal of Biological Chemistry. ,vol. 255, pp. 10431- 10435 ,(1980) , 10.1016/S0021-9258(19)70482-7
Carol Cowing, Howard B. Dickler, Benjamin D. Schwartz, Macrophage Ia Antigens I. Macrophage Populations Differ in Their Expression of Ia Antigens Journal of Immunology. ,vol. 120, pp. 378- 384 ,(1978)
M.P. Osborne, V.J. Richardson, K. Jeyasing, Brenda E. Ryman, Radionuclide-labelled liposomes--a new lymph node imaging agent. International Journal of Nuclear Medicine and Biology. ,vol. 6, pp. 75- 83 ,(1979) , 10.1016/0047-0740(79)90001-9
Amelia Cudd, Henri Labbe, Monique Gervais, Claude Nicolau, Liposomes injected intravenously into mice associate with liver mitochondria Biochimica et Biophysica Acta (BBA) - Biomembranes. ,vol. 774, pp. 169- 180 ,(1984) , 10.1016/0005-2736(84)90288-8
P. Freychet, J. Roth, D. M. Neville, Insulin Receptors in the Liver: Specific Binding of [125I]Insulin to the Plasma Membrane and Its Relation to Insulin Bioactivity Proceedings of the National Academy of Sciences of the United States of America. ,vol. 68, pp. 1833- 1837 ,(1971) , 10.1073/PNAS.68.8.1833
J. Weinstein, S Yoshikami, P Henkart, R Blumenthal, W. Hagins, Liposome-cell interaction: Transfer and intracellular release of a trapped fluorescent marker Science. ,vol. 195, pp. 489- 492 ,(1977) , 10.1126/SCIENCE.835007
Claudine Kieda, Annie-Claude Roche, Francis Delmotte, Michel Monsigny, Lymphocyte membrane lectins. Direct visualization by the use of fluoresceinyl-glycosylated cytochemical markers FEBS Letters. ,vol. 99, pp. 329- 332 ,(1979) , 10.1016/0014-5793(79)80984-9
Graeme I. Bell, Raymond Pictet, William J. Rutter, Analysis of the regions flanking the human insulin gene and sequence of an Alu family member Nucleic Acids Research. ,vol. 8, pp. 4091- 4110 ,(1980) , 10.1093/NAR/8.18.4091
C. Nicolau, A. Le Pape, P. Soriano, F. Fargette, M. F. Juhel, In vivo expression of rat insulin after intravenous administration of the liposome-entrapped gene for rat insulin I. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 80, pp. 1068- 1072 ,(1983) , 10.1073/PNAS.80.4.1068