Increasing donor chimerism and inducing tolerance to islet allografts by post-transplant donor lymphocyte infusion.

摘要: Inducing donor chimerism is the most consistently successful approach to achieve transplant tolerance. We found that a low level of chimerism, which was induced by relatively non-toxic approach, donor-specific tolerance islet allografts in chemically diabetic mice. However, similar could not protect non-obese (NOD) mice spontaneously developed autoimmune diabetes. Rejection NOD with mediated recurrent autoimmunity. used post-transplant lymphocyte infusion (DLI) increase and induce allografts. DLI significantly increased promoted Self-tolerance autoantigens restored restoring self-tolerance immunoregulation. Thus, our data showed adoptive immunotherapy after establishing as platform enhances induces restores setting Our also central sufficient peripheral through immunoregulation for required