Characterization of HLA alleles with locus-specific DNA probes

作者: Beverly H. Koller , Harry T. Orr

DOI:

关键词: Molecular biologyUntranslated regionGeneticsHuman leukocyte antigenLocus (genetics)BiologyHybridization probeAlleleDNA

摘要: HLA class I and II locus specific DNA probes are prepared by cloning segments obtained from the 3'-untranslated region 5' flanking of isolated alleles. The useful to determine alleles present in an individual.

参考文章(3)
Ashwani Sood, Dennis Pereira, Sherman M Weissman, Method for cloning genes ,(1981)
D. Cohen, P. Paul, M. P. Font, O. Cohen, B. Sayagh, A. Marcadet, M. Busson, G. Mahouy, H. M. Cann, J. Dausset, Analysis of HLA class I genes with restriction endonuclease fragments: implications for polymorphism of the human major histocompatibility complex Proceedings of the National Academy of Sciences of the United States of America. ,vol. 80, pp. 6289- 6292 ,(1983) , 10.1073/PNAS.80.20.6289
Larry Edward Morrison, Michael James Heller, William Dudley Prevatt, Cavit Akin, Light-emitting polynucleotide hybridization diagnostic method ,(1982)