Non-selective cyclooxygenase inhibition before periodic acceleration (pGz) cardiopulmonary resuscitation (CPR) in a porcine model of ventricular fibrillation.

摘要: Whole body periodic acceleration (pGz) along the spinal axis is a novel method of cardiopulmonary resuscitation (CPR). Oscillatory motion supine in horizontal fashion provides ventilation and blood flow to vital organs during cardiac arrest pulsatile shear stress vascular endothelium. We previously showed pigs that pGz-CPR affords better overall survival, post myocardial function, neurological outcomes compared conventional chest compression CPR. pGz through on endothelium elicits acute production prostaglandins endothelial-derived nitric oxide (eNO) whole animal models vitro preparations. The salutary effects associated with CPR are part related oxide. Both eNO cardioprotective ischemia reperfusion models. To differentiate between roles these mediators, indomethacin non-selective cyclooxygenase inhibitor (COX) was used as tool investigate prostaglandin by cardioprotection regional flows (RBF). Two groups anesthetized, intubated weighing 25-36kg were studied. Prior electrical induction ventricular fibrillation (VF) animals received equal volumes either saline placebo Control (CONT) (n=9) or (INDO), (n=8), (2mg/kg). After 3min unsupported VF, both 15min followed pharmacologic attempts for resuscitation. Return circulation (ROSC) 3h occurred (78%) CONT (63%) INDO pretreated animals. There no statistically significant difference hemodynamics at baseline protocol. At baseline, caused decrease brain RBF. hours after ROSC, blunted hyperemia response heart. Echocardiographic evidence dysfunction most notable group wall score index (WMSI). ROSC there 4-fold creatine phosphokinase (CPK) Troponin I concentration CONT. Therefore, non-specific inhibition COX blunts pGz-CPR. These data suggest involved cardio protection induced