Molecular testing in melanoma.

摘要: Melanoma is the deadliest form of skin cancer and increasing in incidence. Recent treatment advances have been made, but there remains a need for continued development effective therapy options, as rarely leads to cure. Many melanomas contain somatic mutations involved tumor pathogenesis. Accurate identification these necessary stratify patients purpose potential clinical trials, given absence or presence specific mutation. There are number techniques available that will identify genetic genomic aberrations present within melanoma samples which reviewed here. The type mutation sample drive selection detection strategy. strengths weaknesses, along with limitations, various methods also be discussed. discovery integral increase our understanding pathogenesis should facilitate relevant decisions, advancing progress toward personalized medicine.