Lung microbiota across age and disease stage in cystic fibrosis.

摘要: Understanding the significance of bacterial species that colonize and persist in cystic fibrosis (CF) airways requires a detailed examination community structure across broad range age disease stage. We used 16S ribosomal RNA sequencing to characterize lung microbiota 269 CF patients spanning 60 year range, including 76 pediatric samples from 4–17, cross-section status identify features their relationship stage age. The shows significant inter-individual variability structure, composition diversity. core consists five genera - Streptococcus, Prevotella, Rothia, Veillonella Actinomyces. CF-associated pathogens such as Pseudomonas, Burkholderia, Stenotrophomonas Achromobacter are less prevalent than genera, but have strong tendency dominate when present. Community diversity function greatest 10 years lower older groups, plateauing at approximately 25. Lower correlates with worse multivariate regression model. Infection by Pseudomonas age-associated trends function.