Longitudinal analysis of Plasmodium sporozoite motility in the dermis reveals component of blood vessel recognition

摘要: Malaria remains a devastating disease in many parts of the world. parasites enter host via skin, where they are deposited by infected mosquitoes as look for blood. The must exit skin to reach liver, multiply and ultimately infect red blood cells, cause symptoms disease. In move find vessels that travel circulation liver. Only about 10–20% make it out making this bottleneck parasite. Scientists have been working develop vaccines would protect people against malaria. One way these could work be stop malaria from leaving entering vessels. But do that, more needs learnt how Hopp et al., using mouse model malaria, created produce fluorescent protein allows tracked after injected into mouse's ear. This revealed two ways moving. After first being injected, quickly freely. slow down when come close vessel on or around some time before it. During stage movement, tend paths follow curvature vessels, which may improve well contact with surface enable them areas best suited entry. Next, al. investigated parasite mutants through skin. Both had previously found less likely than wild-type inoculation site. one moves slowly so explores smaller tissue volume normal encounters fewer second mutant spends moving but finds difficult them. Continuing will allow us learn interactions between turn reveal key events targeted vaccine. Furthermore, significant amount spend looking good target antibodies prevent infection.