IgE-dependent release of leukotriene C4 from alveolar macrophages.
作者： John A. Rankin , Margaret Hitchcock , William Merrill , Michael K. Bach , John R. Brashler
DOI: 10.1038/297329A0
关键词: Leukotriene C4 、 Immune system 、 Chemistry 、 Immunoglobulin E 、 Receptor 、 Macrophage 、 Immunology 、 Antigen 、 Cytotoxic T cell 、 Antibody
摘要: Slow reacting substances (SRS) are potent bronchoconstrictors that thought to be important in the pathophysiology of asthma1. Human2–5 and animal6,7 lung fragments release SRS when sensitized by IgE antibody challenged with specific antigen. have been shown recently a family peptidolipids called leukotrienes (LTC4, LTD4 LTE4) derived from arachidonic acid8–11 vivo vitro12,14. It is not known which cell(s) responsible for releasing but two recent observations directed our attention alveolar macrophages. First, Capron co-workers demonstrated serum rats immune Schistosoma mansoni parasites could cause rat peritoneal macrophages cytotoxic schistosomules vitro15. This result interaction macrophage Fc receptors16. Similar receptors also present on macrophages17. Second, Bach Brashler18–21 established mixture LTC4 stimulated calcium ionophore A23187. We now show can activated and, antigen, LTC4.
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sci-hub.se 参考文章(37)
Jean-Paul Dessaint, Gérard Torpier, Monique Capron, Hervé Bazin, André Capron, Cytophilic binding of IgE to the macrophage. I. Binding characteristics of IgE on the surface of macrophages in the rat. Cellular Immunology. ,vol. 46, pp. 12- 23 ,(1979) , 10.1016/0008-8749(79)90241-7
Brooks Cd, Neerken Aj, Bach Mk, Brashler, Slow Reacting Substances: Comparison of Some Properties of Human Lung SRS-A and Two Distinct Fractions from Ionophore-Induced Rat Mononuclear Cell SRS Journal of Immunology. ,vol. 122, pp. 160- 165 ,(1979)
Orange Rp, Ishizaka K, Ishizaka T, Austen Kf, The Capacity of Human Immunoglobulin E to Mediate the Release of Histamine and Slow Reacting Substance of Anaphylaxis (SRS-A) from Monkey Lung Journal of Immunology. ,vol. 104, pp. 335- 343 ,(1970)
B Samuelsson, M K Bach, S Hammarström, J R Brashler, Identification of leukotriene C-1 as a major component of slow-reacting substance from rat mononuclear cells. Journal of Immunology. ,vol. 125, pp. 115- 117 ,(1980)
Thomas A. E. Platts-Mills, Local Production of IgG, IgA, and IgE Antibodies in Grass Pollen Hay Fever Journal of Immunology. ,vol. 122, pp. 2218- 2225 ,(1979)
E. L. Ferry, C. A. Molinaro, J. W. Bohn, N. R. Klinman, L. A. Sherman, D. H. Katz, Fu-Tong Liu, H. Yamamoto, Monoclonal dinitrophenyl-specific murine IgE antibody: preparation, isolation, and characterization. Journal of Immunology. ,vol. 124, pp. 2728- 2737 ,(1980)
Jean-Paul Dessaint, André Capron, Michel Joseph, Hervé Bazin, Cytophilic binding of IgE to the macrophage: II. Immunologic release of lysosomal enzyme from macrophages by IgE and anti-IgE in the rat: A new mechanism of macrophage activation Cellular Immunology. ,vol. 46, pp. 24- 34 ,(1979) , 10.1016/0008-8749(79)90242-9
K. Frank Austen, A. B. Kay, The IgE-mediated release of an eosinophil leukocyte chemotactic factor from human lung. Journal of Immunology. ,vol. 107, pp. 899- 902 ,(1971)
Robert P. Orange, Lawrence M. Lichtenstein, Mary Carol Conroy, Release of Slow Reacting Substance of Anaphylaxis (Srs-A) from Human Leukocytes by the Calcium Ionophore A23187 Journal of Immunology. ,vol. 116, pp. 1677- 1681 ,(1976)
E G Moore, E W Gelfand, R P Orange, The formation and release of slow reacting substance of anaphylaxis (SRS-A) by rat and mouse peritoneal mononuclear cells induced by ionophore A23187. Journal of Immunology. ,vol. 124, pp. 2264- 2267 ,(1980)