Blockade of EGFR and MEK Intercepts Heterogeneous Mechanisms of Acquired Resistance to Anti-EGFR Therapies in Colorectal Cancer
作者： S. Misale , S. Arena , S. Lamba , G. Siravegna , A. Lallo
DOI: 10.1126/SCITRANSLMED.3007947
关键词: Immunology 、 KRAS 、 MAPK/ERK pathway 、 Panitumumab 、 Cancer research 、 Cetuximab 、 Neuroblastoma RAS viral oncogene homolog 、 Blockade 、 EGFR inhibitors 、 Growth factor receptor 、 Medicine
摘要: Colorectal cancers (CRCs) that are sensitive to the anti–epidermal growth factor receptor (EGFR) antibodies cetuximab or panitumumab almost always develop resistance within …
sciencemag.org
elsevier.com参考文章(47)
M. S. Edwards, S. D. Chadda, Z. Zhao, B. L. Barber, D. P. Sykes, A systematic review of treatment guidelines for metastatic colorectal cancer. Colorectal Disease. ,vol. 14, ,(2012) , 10.1111/J.1463-1318.2011.02765.X
Francesco Prati, Maria Cera, Vito Ramazzotti, Fabrizio Imola, Rocco Giudice, Marco Giudice, Silvia De Propris, Mario Albertucci, From bench to bedside Japanese Circulation Journal-english Edition. ,vol. 72, pp. 839- 843 ,(2008) , 10.1253/CIRCJ.72.839
Christopher J. Lord, Sarah McDonald, Sally Swift, Nicholas C. Turner, Alan Ashworth, A High-Throughput RNA Interference Screen for DNA Repair Determinants of PARP Inhibitor Sensitivity DNA Repair. ,vol. 7, pp. 2010- 2019 ,(2008) , 10.1016/J.DNAREP.2008.08.014
L. V. Sequist, B. A. Waltman, D. Dias-Santagata, S. Digumarthy, A. B. Turke, P. Fidias, K. Bergethon, A. T. Shaw, S. Gettinger, A. K. Cosper, S. Akhavanfard, R. S. Heist, J. Temel, J. G. Christensen, J. C. Wain, T. J. Lynch, K. Vernovsky, E. J. Mark, M. Lanuti, A. J. Iafrate, M. Mino-Kenudson, J. A. Engelman, Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors Science Translational Medicine. ,vol. 3, ,(2011) , 10.1126/SCITRANSLMED.3002003
Zhenfeng Zhang, Jae Cheol Lee, Luping Lin, Victor Olivas, Valerie Au, Thomas LaFramboise, Mohamed Abdel-Rahman, Xiaoqi Wang, Alan D Levine, Jin Kyung Rho, Yun Jung Choi, Chang-Min Choi, Sang-We Kim, Se Jin Jang, Young Soo Park, Woo Sung Kim, Dae Ho Lee, Jung-Shin Lee, Vincent A Miller, Maria Arcila, Marc Ladanyi, Philicia Moonsamy, Charles Sawyers, Titus J Boggon, Patrick C Ma, Carlota Costa, Miquel Taron, Rafael Rosell, Balazs Halmos, Trever G Bivona, Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer Nature Genetics. ,vol. 44, pp. 852- 860 ,(2012) , 10.1038/NG.2330
Andrea Bertotti, Giorgia Migliardi, Francesco Galimi, Francesco Sassi, Davide Torti, Claudio Isella, Davide Corà, Federica Di Nicolantonio, Michela Buscarino, Consalvo Petti, Dario Ribero, Nadia Russolillo, Andrea Muratore, Paolo Massucco, Alberto Pisacane, Luca Molinaro, Emanuele Valtorta, Andrea Sartore-Bianchi, Mauro Risio, Lorenzo Capussotti, Marcello Gambacorta, Salvatore Siena, Enzo Medico, Anna Sapino, Silvia Marsoni, Paolo M Comoglio, Alberto Bardelli, Livio Trusolino, None, A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer. Cancer Discovery. ,vol. 1, pp. 508- 523 ,(2011) , 10.1158/2159-8290.CD-11-0109
Floriana Morgillo, T Cascone, E D'aiuto, Erika Martinelli, Teresa Troiani, P Saintigny, Raffaele De Palma, JV Heymach, Liberato Berrino, C Tuccillo, Fortunato Ciardiello, None, Antitumour efficacy of MEK inhibitors in human lung cancer cells and their derivatives with acquired resistance to different tyrosine kinase inhibitors. British Journal of Cancer. ,vol. 105, pp. 382- 392 ,(2011) , 10.1038/BJC.2011.244
J. A. Engelman, K. Zejnullahu, T. Mitsudomi, Y. Song, C. Hyland, J. O. Park, N. Lindeman, C.-M. Gale, X. Zhao, J. Christensen, T. Kosaka, A. J. Holmes, A. M. Rogers, F. Cappuzzo, T. Mok, C. Lee, B. E. Johnson, L. C. Cantley, P. A. Janne, MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling Science. ,vol. 316, pp. 1039- 1043 ,(2007) , 10.1126/SCIENCE.1141478
William Pao, Vincent A Miller, Katerina A Politi, Gregory J Riely, Romel Somwar, Maureen F Zakowski, Mark G Kris, Harold Varmus, Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain PLoS Medicine. ,vol. 2, pp. e73- ,(2005) , 10.1371/JOURNAL.PMED.0020073
Susumu Kobayashi, Titus J. Boggon, Tajhal Dayaram, Pasi A. Jänne, Olivier Kocher, Matthew Meyerson, Bruce E. Johnson, Michael J. Eck, Daniel G. Tenen, Balázs Halmos, EGFR Mutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib The New England Journal of Medicine. ,vol. 352, pp. 786- 792 ,(2005) , 10.1056/NEJMOA044238