Endoscopic Injection of Mitomycin C for the Treatment of Pharyngoesophageal Stenosis Refractory to Endoscopic Treatment with Dilatation in Patients Treated for Head and Neck Cancer.
作者： Carla Cristina Gusmon-Oliveira , Yeda Mayumi Kuboki , Gustavo Andrade de Paulo , Marcelo Simas de Lima , Ricardo Sato Uemura
DOI: 10.1155/2018/5428157
关键词: Stenosis 、 Surgery 、 Neck pain 、 Dysphagia 、 Head and neck cancer 、 Prospective cohort study 、 Adverse effect 、 Endoscopic injection 、 Mitomycin C 、 Medicine
摘要: Background. Management of pharyngoesophageal stenosis (PES) in patients after head and neck cancer (HNC) treatment remains a challenge. It is not uncommon that PES refractory to dilation sessions. This study aimed at evaluating the efficacy Mitomycin C (MMC) endoscopic injection for stenosis. Patients methods. prospective with dysphagia following treatment, without evidence suggestive tumor recurrence, treatment. These were submitted stenotic segment thermoplastic bougies, followed by MMC. We repeated sessions every three weeks. Results. From January 2015 May 2015, we treated 13 PES. Three initially enrolled stricture. observed adverse events all them, intense pain ulcer development, justifying interruption trial. Conclusion. The short interval MMC recommended, because it resulted serious events.
hindawi.com参考文章(19)
Yin Zhang, Xiang Wang, Li LIU, Jian Ping Chen, Zhi Ning Fan, Intramuscular injection of mitomycin C combined with endoscopic dilation for benign esophageal strictures Journal of Digestive Diseases. ,vol. 16, pp. 370- 376 ,(2015) , 10.1111/1751-2980.12255
Ryan Law, Karthik Ravi, Jeffrey A. Alexander, A rash decision Gastroenterology. ,vol. 144, pp. 884- 1158 ,(2013) , 10.1053/J.GASTRO.2013.01.012
Bret J. Spier, Vincent A. Sawma, Deepak V. Gopal, Mark Reichelderfer, Intralesional mitomycin C: successful treatment for benign recalcitrant esophageal stricture Gastrointestinal Endoscopy. ,vol. 69, pp. 152- 153 ,(2009) , 10.1016/J.GIE.2008.05.060
Reza Rahbar, Dwight T. Jones, Roger C. Nuss, David W. Roberson, Margaret A. Kenna, Trevor J. McGill, Gerald B. Healy, The Role of Mitomycin in the Prevention and Treatment of Scar Formation in the Pediatric Aerodigestive Tract: Friend or Foe? Archives of Otolaryngology-head & Neck Surgery. ,vol. 128, pp. 401- 406 ,(2002) , 10.1001/ARCHOTOL.128.4.401
C Blake Simpson, Joshua C. James, The efficacy of mitomycin-C in the treatment of laryngotracheal stenosis. Laryngoscope. ,vol. 116, pp. 1923- 1925 ,(2006) , 10.1097/01.MLG.0000235934.27964.88
M. Boyd Gillespie, Terry A. Day, Anand K. Sharma, Martin B. Brodsky, Bonnie Martin-Harris, Role of mitomycin in upper digestive tract stricture Head and Neck-journal for The Sciences and Specialties of The Head and Neck. ,vol. 29, pp. 12- 17 ,(2007) , 10.1002/HED.20476
Mark H. Mellow, Endoscopic Laser Therapy for Malignancies Affecting the Esophagus and Gastroesophageal Junction Archives of Internal Medicine. ,vol. 145, pp. 1443- 1446 ,(1985) , 10.1001/ARCHINTE.1985.00360080117017
Chul Ho Jang, Chang-Hun Song, Sok Cheon Pak, Effect of exposure to mitomycin C on cultured tympanic membrane fibroblasts International Journal of Pediatric Otorhinolaryngology. ,vol. 67, pp. 173- 176 ,(2003) , 10.1016/S0165-5876(02)00367-1
Mark L. Urken, Adam S. Jacobson, Cathy L. Lazarus, Comprehensive approach to restoration of function in patients with radiation-induced pharyngoesophageal stenosis: report of 31 patients and proposal of new classification scheme. Head and Neck-journal for The Sciences and Specialties of The Head and Neck. ,vol. 34, pp. 1317- 1328 ,(2012) , 10.1002/HED.21927
H. Machida, K. Tominaga, H. Minamino, S. Sugimori, H. Okazaki, H. Yamagami, T. Tanigawa, K. Watanabe, T. Watanabe, Y. Fujiwara, T. Arakawa, Locoregional mitomycin C injection for esophageal stricture after endoscopic submucosal dissection. Endoscopy. ,vol. 44, pp. 622- 625 ,(2012) , 10.1055/S-0032-1306775