N-Cadherin Locks Left-Right Asymmetry by Ending the Leftward Movement of Hensen’s Node Cells

摘要: Summary The stereotypic left-right (LR) asymmetric distribution of internal organs is due to an molecular cascade in the lateral plate mesoderm (LPM) that originated at embryonic node. In chicken embryos, asymmetries Hensen's node are created by leftward cell movements occur transiently. What terminates these movements, and, moreover, what impact prolonging them on LR asymmetry cascade? We show last longer when N-cadherin function blocked and cease prematurely overexpressed right side prolonged lead loss expression fgf8 nodal region. This originates abnormal genes cer1 snai1 LPM, resulting mispositioned hearts. conclude stops this termination is an essential step establishment asymmetry.