Reproducibility of metabolic measurements in malignant tumors using FDG PET.

摘要: PET using 18F-fluorodeoxyglucose (FDG) is increasingly applied to monitor the response of malignant tumors radiotherapy and chemotherapy. The aim this study was assess reproducibility serial FDG measurements define objective criteria for evaluation treatment-induced changes. Methods: Sixteen patients participating in phase I studies novel antineoplastic compounds were examined twice by within 10 d while they receiving no therapy. Standardized uptake values (SUVs), net influx constants (Kj), glucose normalized SUVs (SUVgluc) (Kj,gluc) w ere determined 50 separate lesions. precision repeated on a lesion-by-lesion patient-by-patient basis. Results: None parameters showed significant increase or decrease at two examinations. differences approximately nor mally distributed all with an SD mean percentage difference about 10%. 95% normal ranges spontaneous fluctuations SUV, SUVgluc, Kj Kj,gluc be ±0.91, ±1.14, ±0.52 mL/100 g/min ±0.64 g/min, respectively. Analysis basis yielded similar results. Conclusion: provides several highly reproducible quantitative tumor metabolism. Changes parameter that are outside range may used metabolic