Exposure to Oral Bisphosphonates and Risk of Esophageal Cancer

摘要: Context Use of oral bisphosphonates has increased dramatically in the United States and elsewhere. Esophagitis is a known adverse effect bisphosphonate use, recent reports suggest link between use esophageal cancer, but this not been robustly investigated. Objective To investigate association cancer. Design, Setting, Participants Data were extracted from UK General Practice Research Database to compare incidence gastric cancer cohort patients treated with January 1996 December 2006 control cohort. Cancers identified relevant Read/Oxford Medical Information System codes patient’s clinical files. Cox proportional hazards modeling was used calculate hazard ratios 95% confidence intervals for risk users compared nonusers, adjustment potential confounders. Main Outcome Measure Hazard ratio nonusers. Results Mean follow-up time 4.5 4.4 years cohorts, respectively. Excluding less than 6 months’ follow-up, there 41826 members each (81% women; mean age, 70.0 (SD, 11.4) years). One hundred sixteen or cancers (79 esophageal) occurred 115 (72 The combined 0.7 per 1000 person-years both cohorts; alone cohorts 0.48 0.44 risk, There no difference any (adjusted ratio, 0.96 [95% interval, 0.74-1.25]) only 1.07 0.77-1.49]). also by duration intake. Conclusion Among Database, significantly associated incident