Hexagonal Liquid Crystalline Nanodispersions Proven Superiority for Enhanced Oral Delivery of Rosuvastatin: In Vitro Characterization and In Vivo Pharmacokinetic Study

摘要: Abstract This study aimed to explore the potential of tailoring liquid crystalline structure for augmenting oral absorption and biopharmaceutical performance rosuvastatin. Rosuvastatin (ROS)-loaded nanodispersions (LCNDs) were prepared via emulsification technique. The effect incorporating oleic acid (OA) in various proportions lipid domain LCNDs was studied. formulations characterized particle size, zeta potential, in vitro release, ex vivo intestinal permeation, in vivo bioavailability, stability. All possessed uniform nanometric size negative potential. Employing OA enhanced ROS entrapment efficiency, resulted structural transition from cubic hexagonal phase as proved by transmission electron microscopy. Increasing proportion up a certain ratio prolonged drug release rate, after which further increase had no significant effect. bearing provided enhancement permeation compared glyceryl monooleate cubical nanodispersion demonstrated an outstanding maintaining higher plasma levels 8 h enhancing bioavailability commercial tablet. They be promising carriers improved delivery with substantial effects, superiority cubosomes emulsion.