Cytotoxic activity of aminoderivatized cationic chitosan derivatives
作者： Jung-Kul Lee , Hyun-Soo Lim , Jung-Hoe Kim , None
DOI: 10.1016/S0960-894X(02)00530-9
关键词: Biological activity 、 Structure–activity relationship 、 Chemistry 、 Reductive amination 、 Cytotoxicity 、 Chitin 、 Polysaccharide 、 Combinatorial chemistry 、 Chitosan 、 Cationic polymerization 、 Stereochemistry
摘要: Chitosan derivatives were prepared by dialkylaminoalkylation and reductive amination followed quaternization. In this study, the cytotoxic activity of chitosan was investigated a relationship between structure is suggested. The cationic elicited dose-dependent inhibitory effects on proliferation tumor cell lines.
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