Amplification of Proto-oncogenes in Tumorigenesis
作者： J. Michael Bishop
DOI: 10.1007/978-1-4612-4958-0_9
关键词: Biology 、 Gene 、 Carcinogenesis 、 Gene expression 、 Proto-Oncogenes 、 Human epidermal growth factor receptor 、 On cells 、 Cancer research
摘要: The search for genetic damage in neoplastic cells has become a central theme of contemporary cancer research. Two sorts have been sought: (a) lesions that alter the expression otherwise normal genes, and (b) change functions gene products. Both found, both may play role genesis human neoplasia [1]. Here I review evidence one often-neglected abnormality—the spontaneous amplification DNA—may impose tumorigenic burden on by enforcing inordinate expression.
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