Clinical significance of molecular expression profiles of Hürthle cell tumors of the thyroid gland analyzed via tissue microarrays.

摘要: Hurthle cell tumors are rare thyroid neoplasms for which disease biology is poorly understood and diagnosis of carcinoma can be challenging. The aim the study was to characterize molecular expression profiles determine clinical significance identified phenotypes. Paraffin-embedded tissue cores normal ( n = 18), histopathologically well-defined adenomas 27), unknown malignant behavior 7), minimally 14) widely 21) invasive carcinomas were arrayed in triplicate on microarrays. Expression p53, mdm-2, p21, Bcl-2, cyclin D1, Ki-67 detected by immunohistochemistry correlated with clinicopathological data patient outcome using standard statistical methodology. Median follow-up time 8 years. High proliferative index evident only clinically aggressive associated significantly reduced relapse-free P 0.001) disease-specific 0.04) survival 0.01) Ki-67(+)/Bcl-2(−) phenotype