Evolution versus constitution: differences in chromosomal inversion.

摘要: We compared the chromosomal breakpoints of evolutionary conserved and constitutional inversions. Multicolor banding human-specific bacterial artificial chromosomes were applied to map pericentric inversions on human 2 9. For first time, we present a high-resolution analysis breakpoint regions, which are characterized by gene destitution, co-localization with fragile sites, multitude repeats as well pseudogenes and, remarkably, large sequence homology opposite breakpoint. In contrast, inversion lack such extensive cross-hybridizing regions often associated sites genome low-copy repeats. These molecular characteristics gave evidence for different types formation indicate that cannot originate from like those Finally, investigated three great ape species four test persons each bearing same cytogenetically determined 9, respectively. Our data existence two variant chromosomes.