The Evolutionary Rate of Nonpathogenic Simian Immunodeficiency Virus (SIVagm) Is in Agreement with a Rapid and Continuous Replicationin Vivo

摘要: Abstract African green monkeys (AGMs) are divided into four species ( Cercopithecus aethiops, C. pygerythrus, sabaeus, tantalus ), each harboring a species-specific simian immunodeficiency virus (SIVagm). Little is known about the host and/or viral factors that responsible for apathogenicity of SIVagm infections in their natural hosts. In order to analyze specific selective pressures exerted by on vivo, we compared genetic evolution SIVagm.tan its ) and foreign Erythrocebus patas which could obtain reproducible persistent infection SIVagm.tan. As AGMs, do not develop any disease following infection. Our longitudinal study env (V3-C3-V4-C4-V5) from three AGMs revealed high ratio synonymous nonsynonymous mutation frequencies (1.5–6.2). These data indicate stability override positive selection change reported pathogenic HIV-1 infections. The rapid accumulation mutations observed (0.4–7.2 × 10 −2 nucleotide substitutions per site year) suggests continuous replication viruses vivo. We thus propose nonpathogenic result long-term variants whose dissemination can be controlled host, rather than being explained low ability replicate