The Specific Roles of JAK/STAT Signaling Pathway in Sepsis

作者: Bin Cai , Jian-ping Cai , Yu-long Luo , Cheng Chen , Sen Zhang

DOI: 10.1007/S10753-015-0135-Z

关键词: PhosphorylationSepsisJAK-STAT signaling pathwayCytokineCancer researchActivator (genetics)Signal transductionKinasestatImmunologyMedicine

摘要: … -microbial interaction and believed to play a crucial role in the … the functional role of Stat3 in innate immune cells during … mice with Stat3 deficiency in macrophages and neutrophils were …

参考文章(73)
C. Schindler, S. Gupta, H. Yan, L. H. Wong, S. Ralph, J. Krolewski, The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signals. The EMBO Journal. ,vol. 15, pp. 1075- 1084 ,(1996) , 10.1002/J.1460-2075.1996.TB00445.X
Hj Klasen, Maarten Nijsten, ten Henk Jan Duis, M Helle, La Aarden, Ce Hack, INTERLEUKIN-6 AND ITS RELATION TO THE HUMORAL IMMUNE-RESPONSE AND CLINICAL-PARAMETERS IN BURNED PATIENTS Surgery. ,vol. 109, pp. 761- 767 ,(1991)
Ali Akbar Rahim Rahimi, Katrina Gee, Sasmita Mishra, Wilfred Lim, Ashok Kumar, None, STAT-1 mediates the stimulatory effect of IL-10 on CD14 expression in human monocytic cells. Journal of Immunology. ,vol. 174, pp. 7823- 7832 ,(2005) , 10.4049/JIMMUNOL.174.12.7823
Ju-Hyun Kim, Seon-Ju Kim, Im-Soon Lee, Myung-Shik Lee, Satoshi Uematsu, Shizuo Akira, Kwon Ik Oh, None, Bacterial Endotoxin Induces the Release of High Mobility Group Box 1 via the IFN-β Signaling Pathway Journal of Immunology. ,vol. 182, pp. 2458- 2466 ,(2009) , 10.4049/JIMMUNOL.0801364
Niels C. Riedemann, Thomas A. Neff, Ren-Feng Guo, Kurt D. Bernacki, Ines J. Laudes, J. Vidya Sarma, John D. Lambris, Peter A. Ward, Protective Effects of IL-6 Blockade in Sepsis Are Linked to Reduced C5a Receptor Expression Journal of Immunology. ,vol. 170, pp. 503- 507 ,(2003) , 10.4049/JIMMUNOL.170.1.503
F P Heinzel, The role of IFN-gamma in the pathology of experimental endotoxemia. Journal of Immunology. ,vol. 145, pp. 2920- 2924 ,(1990)
Claire J Greenhill, Stefan Rose-John, Rami Lissilaa, Walter Ferlin, Matthias Ernst, Paul J Hertzog, Ashley Mansell, Brendan J Jenkins, None, IL-6 Trans-Signaling Modulates TLR4-Dependent Inflammatory Responses via STAT3 Journal of Immunology. ,vol. 186, pp. 1199- 1208 ,(2011) , 10.4049/JIMMUNOL.1002971
Cory M. Hogaboam, Matthew L. Steinhauser, Steven L. Kunkel, Robert M. Strieter, Nickolas W. Lukacs, Multiple roles for IL-12 in a model of acute septic peritonitis. Journal of Immunology. ,vol. 162, pp. 5437- 5443 ,(1999)
Joan K. Riley, Kiyoshi Takeda, Shizuo Akira, Robert D. Schreiber, Interleukin-10 receptor signaling through the JAK-STAT pathway. Requirement for two distinct receptor-derived signals for anti-inflammatory action. Journal of Biological Chemistry. ,vol. 274, pp. 16513- 16521 ,(1999) , 10.1074/JBC.274.23.16513