Role of microRNAs in sepsis

摘要: MicroRNAs have been found to be of high significance in the regulation various genes and processes body. Sepsis is a serious clinical problem which arises due excessive host inflammatory response infection. The non-specific features delayed diagnosis sepsis has matter concern for long time. could enable better help identification stages sepsis. Improved may quicker more effective treatment measures. initial acute transient phase involves secretion pro-inflammatory cytokines causes severe damage. negatively regulate toll-like receptor signaling pathway production during Likewise, microRNAs shown vascular barrier endothelial function They are also involved apoptosis, immunosuppression, organ dysfunction later Their importance at levels pathophysiology discussed along with challenges future perspectives. key players staging suggests that they an important role altering outcome associated