Depression of Macrophage Function by a Factor Produced by Neoplasms: A Mechanism for Abrogation of Immune Surveillance

摘要: The possibility that macrophages mediate surveillance against the development of neoplasms has been receiving increasing support. acquisition, by neoplastic cells, capacity to subvert macrophage function may be an important mechanism which they escape destruction host and become established tumors. Indeed, animals implanted with syngeneic developed depressed migratory ability in vivo chemotactic responsiveness vitro . It therefore seemed plausible might capable producing inhibitors function. present report describes identification such a low molecular weight (6,000 10,000), heat-stable inhibitor murine accumulation chemotaxis was four different but not normal liver, spleen, or inflammatory exudate cells did affect PMN When given numbers increased both frequency tumor rate growth. By function, initial mechanisms.