Application of the Tissue-Engineered Plant Scaffold as a Vascular Patch.
作者： Hualong Bai , Jingan Li , Zhiwei Wang , Peng Sun , Shunbo Wei
关键词: Decellularization 、 Biomedical engineering 、 Tissue engineered 、 Inferior vena cava 、 Scaffold 、 Chemistry 、 Cellulose 、 PLGA 、 In vitro 、 Neointima
摘要: Tissue-engineered plant scaffolds have shown promising applications in vitro studies. To assess the applicability of natural as vascular patches, we tested decellularized leaf and onion cellulose a rat inferior vena cava patch venoplasty model. The was decellularized, scaffold loaded with polylactic-co-glycolic acid (PLGA)-based rapamycin nanoparticles (nanoparticles). Nanoparticle-perfused leaves showed decreased neointimal thickness after implantation on day 14; there were also fewer CD68-positive cells PCNA-positive neointima nanoparticle-perfused patches than control patches. Onion coated nanoparticles, implanted rat; nanoparticle-coated thickness. These data show that plant-based may be used novel for tissue-engineered However, further modifications are needed to enhance strength artery implantations.
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