Correlation of transforming growth factor beta-1 gene polymorphisms C-509T and T869C and the risk of gastric cancer in China.

摘要: Background and Aim:  As an important cytokine that modulate the cell cycle, involvement of transforming growth factor beta-1 (TGF-β1) in carcinogenesis has been extensively studied for many years. Literatures have demonstrated TGF-β1 gene polymorphisms may alter risk various cancers, such as lung, prostate breast. To investigate whether can modify gastric cancer, we conduct this hospital-based, case-control study. Methods:  One hundred sixty-seven cases 193 gender, age-matched healthy controls were enrolled study. C-509T T + 869C identified by PCR-RFLP ARMS-PCR protocols, respectively. Results:  Significantly different distributions both genes between case control. Variant genotypes −509CT, −509TT, +869TC +869CC associated with increased cancer (P = 0.001, OR = 2.54; P = 0.016, OR = 2.09; P < 0.001, OR = 3.46; OR = 4.04, respectively). With haplotype analysis, wild type CT (−509C +869T) led to a lower frequency than control (P < 0.001), while TC was more frequent (P < 0.001). Multiple logistic regression analysis revealed individuals had likelihood developing (OR = 3.19, 95%CI = 1.72–5.90). Conclusions:  Our findings imply −509C > T +869T > C be critical genetic susceptibility Chinese population.