The cellular basis of hybrid dysgenesis and Stellate regulation in Drosophila

摘要: During normal tissue development, the accumulation of unrepaired cellular and genomic damage can impair growth ultimately leads to death. To preserve integrity, cells employ a number defense mechanisms including molecular checkpoints, during which development is halted while dedicated pathways attempt repair. This process most critical in germline tissues where directly threatens an organism's reproductive capacity offspring viability. In fruit fly, Drosophila melanogaster, has been extensively studied for over century breadth our knowledge flourished genomics age. Intriguingly, several peculiar phenomena that trigger catastrophic described decades ago, still endure only partial understanding underlying causes. A deeper reexamination using new genetic tools may greatly benefit host system biology. Among these, focus this concise review, are hybrid dysgenesis intragenomic conflict pits X Y sex chromosomes against each other.