Inducible intracellular membranes: molecular aspects and emerging applications

摘要: Membrane remodeling and phospholipid biosynthesis are normally tightly regulated to maintain the shape function of cells. Indeed, different physiological mechanisms ensure a precise coordination between de novo modulation membrane morphology. Interestingly, overproduction certain proteins hijack these regulation networks, leading formation impressive intracellular structures in both prokaryotic eukaryotic The triggering an abnormal accumulation inside cells (or proliferation) share two major common features: (1) they promote highly curved domains (2) lead enrichment anionic, cone-shaped phospholipids (cardiolipin or phosphatidic acid) newly formed membranes. Taking into account available examples proliferation upon protein overproduction, together with latest biochemical, biophysical structural data, we explore relationship synthesis biogenesis. We propose mechanism for non-physiological membranes that shares similarities natural inner found α-proteobacteria, mitochondria some viruses-infected cells, pointing towards conserved feature through evolution. hope information discussed this review will give better grasp behind induced proliferation, inspire new applications, either academia (high-yield production nanovesicle production) industry (biofuel vaccine preparation).