Augmentation of femoral neck fracture fixation with an injectable calcium-phosphate bone mineral cement.

作者: C. J. Stankewich , Marc F. Swiontkowski , Allan F. Tencer , Duran N. Yetkinler , Robert D. Poser

DOI: 10.1002/JOR.1100140516

关键词: MedicineFemoral headFixation (histology)Fracture fixationSurgeryFemoral Neck FracturesFemoral neckBone mineralNuclear medicineCancellous boneFemur

摘要: The first goal of this study was to determine if augmentation with an injectable, in situ setting, calcium-phosphate cement that is capable being remodeled and designed mimic bone mineral significantly improved the strength stiffness fixation a cadaveric femoral neck fracture model. second greater increases were achieved as density specimen decreased. Sixteen pairs fresh human femora mean age 70.9 years (SD = 17.2 years) utilized. measured dual-energy x-ray absorptiometry. head impacted vertically shaft fixed 12 degrees adduction using materials testing machine create fully displaced fracture. Following fracture, 30% inferior comminution created each specimen. One randomly chosen femur from pair underwent anatomic reduction three cannulated cancellous screws, 7 mm diameter, inverted triangle configuration. contralateral same augmented cement. Specimens preconditioned followed by 1.000 cycles one body weight (611.6 N) at 0.5 Hz simulate single-limb stance loading. cycle observed be cement-augmented specimens compared unaugmented controls (p < 0.05). After cycling, loaded 10 mm/min until complete displacement surface failure occurred. failed 4,573 N 1,243 N); 0.01) than for (3,092 N, SD 1,258 N). relative improvement (augmented/control x 100%) not inversely correlated 0.25, R2 0.09), weakly volume injected 0.07, 0.22), related load control 0.001, 0.54). There 169.6% 77.5). These findings suggest provides initial beneficial fractures.

参考文章(15)
Jeffrey C. Lotz, Tobin N. Gerhart, Wilson C. Hayes, Mechanical properties of trabecular bone from the proximal femur: a quantitative CT study. Journal of Computer Assisted Tomography. ,vol. 14, pp. 107- 114 ,(1990) , 10.1097/00004728-199001000-00020
ANTTI ALHO, TORSTEIN HUSBY, ARNE H??SISETH, Bone mineral content and mechanical strength. An ex vivo study on human femora at autopsy. Clinical Orthopaedics and Related Research. ,vol. 227, pp. 292- ,(1988) , 10.1097/00003086-198802000-00035
Pierre M. Witschger, Tobin N. Gerhart, Janet B. Goldman, Laura E. Edsberg, Wilson C. Hayes, Biomechanical evaluation of a biodegradable composite as an adjunct to internal fixation of proximal femur fractures. Journal of Orthopaedic Research. ,vol. 9, pp. 48- 53 ,(1991) , 10.1002/JOR.1100090107
Tobin N. Gerhart, Wilson C. Hayes, Steven H. Stern, Biomechanical optimization of a model particulate composite for orthopaedic applications Journal of Orthopaedic Research. ,vol. 4, pp. 76- 85 ,(1986) , 10.1002/JOR.1100040109
Marc F. Swiontkowski, Richard M. Harrington, Tony S. Keller, Peter K. Van Patten, Torsion and bending analysis of internal fixation techniques for femoral neck fractures: the role of implant design and bone density. Journal of Orthopaedic Research. ,vol. 5, pp. 433- 444 ,(1987) , 10.1002/JOR.1100050316
L.T. Nilsson, H. Franz�n, B. Str�mqvist, I. Wiklund, Function of the hip after femoral neck fractures treated by fixation or secondary total hip replacement. International Orthopaedics. ,vol. 15, pp. 315- 318 ,(1991) , 10.1007/BF00186868
C. J. Stankewich, Jens Chapman, Raman Muthusamy, Gina Quaid, Emil Schemitsch, Allan F. Tencer, Randy P. Ching, Relationship of mechanical factors to the strength of proximal femur fractures fixed with cancellous screws. Journal of Orthopaedic Trauma. ,vol. 10, pp. 248- 257 ,(1996) , 10.1097/00005131-199605000-00005
J. SCHATZKER, G. B. HAʼERI, M. CHAPMAN, Methylmethacrylate as an adjunct in the internal fixation of intertrochanteric fractures of the femur. Journal of Trauma-injury Infection and Critical Care. ,vol. 18, pp. 732- 735 ,(1978) , 10.1097/00005373-197810000-00011
B. Constantz, I. Ison, M. Fulmer, R. Poser, S. Smith, M VanWagoner, J Ross, S. Goldstein, J. Jupiter, D. Rosenthal, Skeletal repair by in situ formation of the mineral phase of bone Science. ,vol. 267, pp. 1796- 1799 ,(1995) , 10.1126/SCIENCE.7892603