Differences in pituitary expression of proopiomelanocortin in Dahl salt-resistant and salt-sensitive rats on a high salt diet.
作者： J Hao , S W Rabkin
DOI: 10.1139/Y96-064
关键词: Salt diet 、 Molecular biology 、 Internal medicine 、 Strain specificity 、 Salt resistance 、 Proopiocortin 、 Proopiomelanocortin 、 Animal model 、 Salt sensitivity 、 Chemistry 、 Cardiovascular control 、 Endocrinology
摘要: Les souches de rats Dahl genetiquement sensibles au sel (S) et resistants (R) s'averent utiles pour examiner les mecanismes sensibilite resistance sel. Des faits ayant demontre que peptides opioides leurs recepteurs peuvent contribuer a la regulation cardiovasculaire, l'objectif presente etude ete verifier l'hypothese POMC (proopiomelanocortine), le precurseur β-endorphine, joue un role dans developpement l'hypertension ; ce faire, nous avons determine teneur en ARNm proopiomelanocortine contenue l'hypophyse. S R consanguins, âges 3 semaines, ont soumis soit regime hypersodique (8% NaCl), hyposodique (0,4% NaCl) pendant 6 semaines. L'ARNm et, aux fins comparaison, l'ARNm preproenkephaline A (preproENK) determines tissus des par buvardage Northern, utilisant β-actine comme etalon. etait abondant hypophysaires. plus tissu hypophysaire celui hypersodique. Aucune difference taux d'ARNm n'a observee. preproENK n'ont pas differe hypophysaires l'un ou l'autre regimes. lumiere ces resultats, suggerons qu'une production inefficace termes l'hypophyse constitue une caracteristique du rat
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