The Type 1 growth factor receptors and their ligands considered as a complex system.
作者： W J Gullick
关键词: Second messenger system 、 Gene 、 Bioinformatics 、 Complex system 、 Growth factor receptor 、 Receptor 、 Biology 、 Computational biology
摘要: The Type 1 family of growth factors and their receptors play an important role in normal development, wound healing diseases such as cancer. products the four receptor genes ten specifying ligands interact a complex pattern. Such systems may develop emergent properties which cannot be predicted from reductionist analysis interactions individual components. New methods determining these higher level are, however, being developed. These include microscopic live cells expressing fluorescently tagged ligands, second messengers can provide positional information on components system. Computational simulations are developed help to predict
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endocrinology-journals.org 参考文章(29)
Richard A. Stein, James V. Staros, Evolutionary Analysis of the ErbB Receptor and Ligand Families Journal of Molecular Evolution. ,vol. 50, pp. 397- 412 ,(2000) , 10.1007/S002390010043
Jean-Paul Borg, Sylvie Marchetto, André Le Bivic, Vincent Ollendorff, Fanny Jaulin-Bastard, Hiroko Saito, Emmanuel Fournier, José Adélaïde, Ben Margolis, Daniel Birnbaum, ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor Nature Cell Biology. ,vol. 2, pp. 407- 414 ,(2000) , 10.1038/35017038
Dennis Bray, Matthew D. Levin, Carl J. Morton-Firth, Receptor clustering as a cellular mechanism to control sensitivity Nature. ,vol. 393, pp. 85- 88 ,(1998) , 10.1038/30018
D Wen, S V Suggs, D Karunagaran, N Liu, R L Cupples, Y Luo, A M Janssen, N Ben-Baruch, D B Trollinger, V L Jacobsen, Structural and functional aspects of the multiplicity of Neu differentiation factors. Molecular and Cellular Biology. ,vol. 14, pp. 1909- 1919 ,(1994) , 10.1128/MCB.14.3.1909
William John Gullick, Radhika Srinivasan, The type 1 growth factor receptor family: new ligands and receptors and their role in breast cancer Breast Cancer Research and Treatment. ,vol. 52, pp. 43- 53 ,(1998) , 10.1023/A:1006107016969
W.W.A. Schamel, T.P. Dick, Signal transduction: Specificity of growth factors explained by parallel distributed processing Medical Hypotheses. ,vol. 47, pp. 249- 255 ,(1996) , 10.1016/S0306-9877(96)90088-2
Tony Pawson, Protein modules and signalling networks Nature. ,vol. 373, pp. 573- 580 ,(1995) , 10.1038/373573A0
Helen Gillham, Matthew CHM Golding, Rainer Pepperkok, William J Gullick, None, Intracellular Movement of Green Fluorescent Protein–Tagged Phosphatidylinositol 3-Kinase in Response to Growth Factor Receptor Signaling Journal of Cell Biology. ,vol. 146, pp. 869- 880 ,(1999) , 10.1083/JCB.146.4.869
Richard Torres, Bonnie L Firestein, Hualing Dong, Jeff Staudinger, Eric N Olson, Richard L Huganir, David S Bredt, Nicholas W Gale, George D Yancopoulos, PDZ Proteins Bind, Cluster, and Synaptically Colocalize with Eph Receptors and Their Ephrin Ligands Neuron. ,vol. 21, pp. 1453- 1463 ,(1998) , 10.1016/S0896-6273(00)80663-7
Philippe IH Bastiaens, Anthony Squire, Fluorescence lifetime imaging microscopy: spatial resolution of biochemical processes in the cell Trends in Cell Biology. ,vol. 9, pp. 48- 52 ,(1999) , 10.1016/S0962-8924(98)01410-X